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Financial markets are very liquid, because the US Federal Reserve Bank is trying to avoid a deflation at any cost. Interest rates are very low. 

In the aftermath of The Great Bubble, prices have steeply corrected. Most major markets have now declined on average by 50% or more over the last 3 years. 

On timing, nobody has a perfect answer. We are now in a period of high anxiety, fear and lack of confidence. Prices are very low, but as always, they could go lower. 

Our pharmaceutical companies also had a tough year. They were able to maintain their profitability, but there seem to be very few new blockbuster drugs in the pipeline.